Wine Country.com is a good starting point for information on California wine experiences in each of the major regions of California. This includes lodging, wineries, restaurants, events and things to do. Visit Napa Valley and Visit Sonoma Wine Country are alternative sources for those areas.
Alternatively, California Wine Country Getaways provides self-planning guides for the independent traveller including suggestions on wineries, accommodation, dining options, and detailed driving directions covering all the major wine producing areas.
Wine Tour Operators
California Wine Tours provide day tours of four to five wineries in the Napa or Sonoma valleys. Pickup is from major hotels. They also provide private personalized day tours. They are in Yahoo’s top ten wine tour sites.
Beau Wine Tours provide a variety of day tours starting and finishing in Napa, Sonoma or San Francisco. Destinations from San Francisco include Napa, Sonoma, Russian River, Dry Creek and Alexander Valley. Custom tours can be arranged also. They are in Yahoo’s top ten wine tour sites.
Platypus Wine Tours offer a variety of wine tours in Napa, Sonoma Valley and North Sonoma. Their join-in tours are for six to eight people and consist of a trip to three wineries plus a picnic lunch at one of them. They also offer private (customized) tours under which you specify the number of people and where you want to go. They pick up at most locations.
For other wine tour possibilities, here’s an article entitled The 7 Best San Francisco Wine Tours
Other USA wine regions worth visiting are New York State and Pacific Northwest which includes Oregon and Washington State.